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These outcomes, together with a preceding report showing that a small-molecule ACKR3 agonist CCX771 displays anxiolytic-like conduct in mice,2 assist the idea of targeting ACKR3 as a unique solution to modulate the opioid procedure, which could open new therapeutic avenues for opioid-linked disorders.Tabernaemontana divaricata Conolidine is undoubt